Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva

摘要: Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion. Two embryonic structures accomplish this behavior: the central nervous system (CNS) skeletal muscles. To identify genes that are functionally involved in mediating controlling different larval motility, we included a simple touch response test our zebrafish large-scale genetic screen. In total identified 166 mutants with specific defects motility. These fall into 14 phenotypically distinct groups comprising at least 48 genes. Here describe various phenotypic including no reduced mechanosensory defective mutants, ‘spastic’ circling motor circuit mutants. 63 defining 18 genes, striation somitic muscles is reduced. Phenotypic analysis provides evidence these consecutive functions during muscle development. The sloth (slo) frozen (fro) already act myoblast differentiation, while 13 appear to function later, formation myofibers organization sarcomeres. Mutations four other result muscle-specific degeneration. 103 mutations, 30 cause obvious may instead affect neuronal Analysis behavioral suggests participate diverse locomotion observed, such as response, rhythmic tail movements, equilibrium control, they simply confer general animal. some developing detected. two nevermind (nev) macho (mao), axonal projection optic tectum, whereas axon elongation motorneurons disrupted by mutations diwanka (diw) unplugged (unp)