Adrenal Oncocytic Phaeochromocytoma with Putative Adverse Histologic Features: a Unique Case Report and Review of the Literature

摘要: Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential 68-year-old man. The patient presented an incidental non-functional mass discovered on routine radiological investigation, which was subsequently excised. Histologically, tumour cells showed high-grade nuclear abnormalities foci extension to peri-adrenal fat. Immunohistochemistry performed positive for chromogranin, CD56, S-100 p53 negative inhibin, HMB-45, EMA, AE1/AE3, Cam 5.2 calretinin. Electron microscopy electron dense granules neurosecretory type, confirmed diagnosis. assessed available histologic scoring systems, demonstrated high potential. However, no recurrence detected after 5 years follow-up. Compared all previously phaeochromocytoma, this oldest presentation, only identified has longest A review literature that were non-functional, non-metastasizing described women. conclude, should be differential diagnoses tumours gland. Additional studies needed predict behaviour entity.