Sudden Unexpected Death in Epilepsy: Incidence, Risk Factors, and Proposed Mechanisms.

摘要: Epilepsy is a common neurological disorder associated with increased morbidity and mortality, including premature death from different causes. Sudden unexpected in epilepsy, or SUDEP, one of the most causes people epilepsy originally brought to light by medical examiners. It accounts for 5% 30% all deaths individuals up 50% medically refractory epilepsy. commonly history generalized tonic-clonic seizures may be mitigated other electroclinical risk factors, such as postictal electroencephalographic suppression, prone position, altered heart rate variability, conduction abnormalities, gender, antiepileptic medications, name few. More recently, potential neuroimaging biomarkers have also been identified. Still, despite mortality due little known about its underlying pathophysiology. The pathogenesis likely multifactorial, resulting neurogenic pulmonary edema or, some cases, fatal cardiac arrhythmias. Medical examiners can provide an important role our understanding magnitude problem ongoing research into mechanisms. In this review, we discuss diagnostic criteria, incidence, current theories regarding pathophysiology SUDEP.