Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study

摘要: The midsagittal area of the corpus callosum was measured in its entirety and seven subdivisions a sample 50 brains consecutively obtained from autopsies individuals who had neuropsychological testing before death. A 12-item test hand preference used as an index pattern interhemispheric functional asymmetry. Callosal size analysed for two factors: preference, classified consistent-right-hand (CRH) versus non sex. group nCRH (n = 18) found to have larger overall callosal area, with greatest difference occurring posterior body segments, especially isthmus. isthmus probably includes fibres parietal superior temporal cortex which involves cortical regions related results variation morphology are discussed part possible substrate asymmetry due axonal elimination early brain development. Sex differences were several aspects anatomy. (1) between groups occurred interaction sex:handedness factor males 15), but not females 35). This result is consistent general hypothesis having less clear lateralization than males. (2) Females did or splenium, either absolute proportional weight. latter measure considered since correlated cerebrum weight (r 0.48). In contrast, female both compared CRH (3) Of all regions, only genu anterior be females. (4) decreased chronological age males,