Antitumor vaccination with synthetic mRNA: strategies for in vitro and in vivo preclinical studies.
作者： Mustafa Diken , Sebastian Kreiter , Abderraouf Selmi , Özlem Türeci , Ugur Sahin
DOI: 10.1007/978-1-62703-260-5_15
关键词:
摘要: Synthetic antigen-encoding mRNA is increasingly exploited as a tool for delivery of genetic information of complete antigens into professional antigen presenting dendritic cells for HLA haplotype-independent antigen-specific vaccination against cancer. Two strategies for mRNA-based antitumor vaccination have emerged into the clinical setting. One is transfection of autologous dendritic cells with synthetic mRNA for adoptive transfer into the patient. The other is direct injection of naked synthetic mRNA. Both methods have proven to …
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