Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy.

摘要: We have developed a proton magnetic resonance spectroscopy method that selectively can sample cortical gray matter and adjacent white in the frontal lobe. used this approach to study group of patients (n = 7) infected with HIV clinical manifestations AIDS dementia complex (ADC), 8) without any indications ADC, seven controls. The ADC had statistically significant increase ratio myo-inositol creatine compared normal In contrast, almost levels both showed decrease N-acetylaspartate either controls or ADC. Patterns spectral abnormalities correlated neuropsychological measures lobe dysfunction, suggesting evaluation metabolism by play role early detection determining its progression, assessing responses therapeutic interventions.