Inhibition of fibroblast cell adhesion on substrate by coating with 2-methacryloyloxyethyl phosphorylcholine polymers.
作者： Kazuhiko Ishihara , Eri Ishikawa , Yasuhiko Iwasaki , Nobuo Nakabayashi
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摘要: Fibroblast adhesion and growth behavior were examined on various polymers coated a poly(ethylene telephthalate) (PET) substrate. The are poly[2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate copolymer (PMB)s with different MPC unit compositions, poly(2-hydroxyethyl methacrylate). Surface analysis by dynamic contact angle measurement revealed that the mobility of polymer chain PET substrate depended composition, but there was no significant difference between PMBs 3-10 mol% units poly(HEMA). Fibronectin adsorption surface from cell culture medium determined immunoassay. adsorbed fibronection evenly distrubuted in every polymer, however, amount reduced an increase composition PMB. This result suggested could weaken interaction proteins. When fibroblast L-929 cells, cultured polymers, cells a...
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