Horizontal Transfer of a Subtilisin Gene from Plants into an Ancestor of the Plant Pathogenic Fungal Genus Colletotrichum

摘要: The genus Colletotrichum contains a large number of phytopathogenic fungi that produce enormous economic losses around the world. effect horizontal gene transfer (HGT) has not been studied yet in these organisms. Inter-Kingdom HGT into fungal genomes reported past but knowledge about between plants and is particularly limited. We describe genome several species with strong resemblance to subtilisins typically found plant genomes. Subtilisins are an important group serine proteases, widely distributed all kingdoms life. Our hypothesis was acquired by spp. through from ancestor. provide evidence support this form phylogenetic analyses as well characterization similarity subtilisin at primary, secondary tertiary structural levels. remarkable level conservation plant-like (CPLS) differences rest suggests possibility molecular mimicry. analysis indicates event would have occurred approximately 150–155 million years ago, after divergence lineage other fungi. Gene expression shows modulated during infection maize C. graminicola suggesting it role disease. Furthermore, upregulation CPLS coincides downregulation genes encoding subtilisins. Based on known roles pathogenic pattern we observed, postulate CPLSs infection.