Decreased anticipated pleasure correlates with increased salience network resting state functional connectivity in adolescents with depressive symptomatology
作者： Ewelina Rzepa , Ciara McCabe
DOI: 10.1016/J.JPSYCHIRES.2016.07.013
关键词:
摘要: Previous studies have found dysfunctional resting state functional connectivity (RSFC) in depressed patients. Examining RSFC might aid biomarker discovery for depression. However young people at risk of depression has yet to be examined. 35 healthy adolescents (13–18 yrs old.) were recruited. 17 scoring high on the Mood and Feelings Questionnaire (MFQ > 27 (High Risk: HR), 18 low MFQ < 15 (Low LR) matched age gender. We selected seed regions salience network (SN: amygdala pregenual anterior cingulate cortex (pgACC)) central executive (CEN: dorsal medial prefrontal (dmPFC)). anhedonia measures correlated with brain connectivity. We decreased HR group between pgACC hippocampus precuneus. also putamen dmPFC The insula/orbitofrontal inversely anticipation pleasure all subjects. Increased was observed temporal pole compared LR group. Our findings are first show that symptoms seeds SN CEN nodes Default Mode Network. As increased insula ability anticipate pleasure, we suggest this mechanism underlying experiencing anhedonia, a suggested
core.ac.uk
elsevier.com
journalofpsychiatricresearch.com 参考文章(57)
Garrett E. Alexander, Michael D. Crutcher, Mahlon R. DeLong, Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Progress in Brain Research. ,vol. 85, pp. 119- 146 ,(1991) , 10.1016/S0079-6123(08)62678-3
Tali M. Ball, Murray B. Stein, Martin P. Paulus, Toward the application of functional neuroimaging to individualized treatment for anxiety and depression. Depression and Anxiety. ,vol. 31, pp. 920- 933 ,(2014) , 10.1002/DA.22299
Tieme W.P. Janssen, Dirk J. Heslenfeld, Rosa van Mourik, Gordon D. Logan, Jaap Oosterlaan, Neural correlates of response inhibition in children with attention-deficit/hyperactivity disorder: A controlled version of the stop-signal task. Psychiatry Research-neuroimaging. ,vol. 233, pp. 278- 284 ,(2015) , 10.1016/J.PSCYCHRESNS.2015.07.007
Julie Frost Bellgowan, Peter Molfese, Michael Marx, Moriah Thomason, Daniel Glen, Jessica Santiago, Ian H. Gotlib, Wayne C. Drevets, J. Paul Hamilton, A neural substrate for behavioral inhibition in the risk for major depressive disorder Journal of the American Academy of Child and Adolescent Psychiatry. ,vol. 54, pp. 841- 848 ,(2015) , 10.1016/J.JAAC.2015.08.001
Mary L Phillips, Wayne C Drevets, Scott L Rauch, Richard Lane, Neurobiology of emotion perception I: the neural basis of normal emotion perception Biological Psychiatry. ,vol. 54, pp. 504- 514 ,(2003) , 10.1016/S0006-3223(03)00168-9
Dorothea I Horn, Chunshui Yu, Johann Steiner, Julia Buchmann, Joern Kaufmann, Annemarie Osoba, Ulf Eckert, Kathrin C Zierhut, Kolja Schiltz, Huiguang He, Bharat Biswal, Bernhard Bogerts, Martin Walter, Glutamatergic and Resting-State Functional Connectivity Correlates of Severity in Major Depression – The Role of Pregenual Anterior Cingulate Cortex and Anterior Insula Frontiers in Systems Neuroscience. ,vol. 4, pp. 33- ,(2010) , 10.3389/FNSYS.2010.00033
Alison Wood, Leo Kroll, Ann Moore, Richard Harrington, Properties of the Mood and Feelings Questionnaire in Adolescent Psychiatric Outpatients: A Research Note Journal of Child Psychology and Psychiatry. ,vol. 36, pp. 327- 334 ,(1995) , 10.1111/J.1469-7610.1995.TB01828.X
Justine Nienke Pannekoek, S.J.A. van der Werff, Paul H.F. Meens, Bianca G. van den Bulk, Dietsje D. Jolles, Ilya M. Veer, Natasja D.J. van Lang, Serge A.R.B. Rombouts, Nic J.A. van der Wee, Robert R.J.M. Vermeiren, Aberrant resting-state functional connectivity in limbic and salience networks in treatment--naïve clinically depressed adolescents. Journal of Child Psychology and Psychiatry. ,vol. 55, pp. 1317- 1327 ,(2014) , 10.1111/JCPP.12266
Amit Anand, Yu Li, Yang Wang, Jingwei Wu, Sujuan Gao, Lubna Bukhari, Vincent P. Mathews, Andrew Kalnin, Mark J. Lowe, Activity and Connectivity of Brain Mood Regulating Circuit in Depression: A Functional Magnetic Resonance Study Biological Psychiatry. ,vol. 57, pp. 1079- 1088 ,(2005) , 10.1016/J.BIOPSYCH.2005.02.021
Conor Liston, Ashley C. Chen, Benjamin D. Zebley, Andrew T. Drysdale, Rebecca Gordon, Bruce Leuchter, Henning U. Voss, B.J. Casey, Amit Etkin, Marc J. Dubin, Default mode network mechanisms of transcranial magnetic stimulation in depression Biological Psychiatry. ,vol. 76, pp. 517- 526 ,(2014) , 10.1016/J.BIOPSYCH.2014.01.023