Association of Depression and Survival in Patients with Chronic Heart Failure over 12 Years

摘要: Objective To examine the relationship between depression and survival in patients with chronic heart failure (HF) over a 12-year follow-up period. Background The associated has been demonstrated HF for up to 7 years. Longer-term impact of on these remains unknown. Methods Prospectively conducted observational study examining adults who were admitted cardiology service at Duke University Medical Center March 1997 June 2003 completed Beck Depression Inventory (BDI) scale. National Death Index was queried vital status. Cox proportional hazards modeling used determine association depression. Results During mean 1792.33 ± 1372.82 days (median 1600; range 0–4683), 733 985 participants died all causes, representing 80% those (BDI > 10) 73% without (P = 0.01). significantly persistently decreased (hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.15–1.57), independent conventional risk factors (HR 1.40, CI 1.16–1.68). Furthermore, inversely severity continuous HR 1.02, 1.006–1.025, P=0.001). Conclusions co-morbid during index hospitalization increased mortality is strong persists 12 These findings suggest that more investigation needed understand trajectory mechanisms underlying as well identify effective management strategies HF.