Merkel cell carcinoma

摘要: BACKGROUND. Currently, little is known regarding the potential prognostic value of histologic features in primary cutaneous neuroendocrine (Merkel cell) carcinomas (MCC). METHODS. In a retrospective review tumor histology and clinical outcome data (median follow-up, 51 months; range, 3-224 months) 156 patients with diagnosis MCC, following were evaluated: thickness, size (greatest dimension tumor), microanatomic compartment involved by (dermis and/or subcutis deeper), growth pattern (nodular circumscribed vs infiltrative), lymphovascular invasion (LVI), tumor-infiltrating lymphocytes, necrosis, ulceration, solar elastosis. RESULTS. The overall 5-year survival rate was 67.5%. On univariate analysis, parameters that associated significantly thickness (P = .001), .0002), deepest anatomic .0003), .003), LVI < .00001), lymphocytes .05), elastosis .04). multivariate presence nodular pattern, low depth, absence longer survival. CONCLUSIONS. In addition to stage, 3 identified have significance: (depth invasion), LVI, pattern. Cancer 2008. © 2008 American Society.