Pathobiology of Renal Carcinogenesis
作者： P. Bannasch , H. Zerban
DOI: 10.1007/978-3-642-76863-7_2
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摘要: The long-standing controversy concerning the histogenesis of kidney cancer, especially so-called hypernephroma (which was taken for a dysontogenetic tumor by Grawitz in 1883), appeared to be settled 30 years ago when Oberling and colleagues (1960) provided persuasive evidence an origin hypernephroid carcinoma from epithelium proximal nephron. Consequently, term replaced renal cell (WHO 1981). Some findings rodents treated with chemical carcinogens seemed long time support conception pivotal role nephron tumors (Lipsky Trump 1988). However, during past decade, several original observations animal models (Bannasch Zerban 1990) number new man (Thoenes et al. 1986; Eble 1990; Kovacs have reopened discussion on cellular origin, mechanism development, classification, prognosis tumors.
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