Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin
作者： T. J. Lindell , F. Weinberg , P. W. Morris , R. G. Roeder , W. J. Rutter
DOI: 10.1126/SCIENCE.170.3956.447
关键词:
摘要: α-Amanitin, a toxic substance from the mushroom Amanita phalloides, is potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) sea urchin, rat liver, and calf thymus. This compound exerts no effect on activity I (nucleolar or III (also nucleoplasmic). The inhibition due to specific interaction with complex DNA II.
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