Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor
作者： Nicholas S Duesbery , Craig P Webb , Stephen H Leppla , Valery M Gordon , Kurt R Klimpel
DOI: 10.1126/SCIENCE.280.5364.734
关键词:
摘要: Anthrax lethal toxin, produced by the bacterium Bacillus anthracis, is major cause of death in animals infected with anthrax. One component this factor (LF), suspected to be a metalloprotease, but no physiological substrates have been identified. Here it shown that LF protease cleaves amino terminus mitogen-activated protein kinase kinases 1 and 2 (MAPKK1 MAPKK2) cleavage inactivates MAPKK1 inhibits MAPK signal transduction pathway. The identification site for may facilitate development inhibitors.
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researchgate.net 参考文章(22)
E.K. Shibuya, T.G. Boulton, M.H. Cobb, J.V. Ruderman, Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest. The EMBO Journal. ,vol. 11, pp. 3963- 3975 ,(1992) , 10.1002/J.1460-2075.1992.TB05490.X
Y Singh, K R Klimpel, N Arora, M Sharma, S H Leppla, The chymotrypsin-sensitive site, FFD315, in anthrax toxin protective antigen is required for translocation of lethal factor. Journal of Biological Chemistry. ,vol. 269, pp. 29039- 29046 ,(1994) , 10.1016/S0021-9258(19)62010-7
D.J. Robbins, E. Zhen, H. Owaki, C.A. Vanderbilt, D. Ebert, T.D. Geppert, M.H. Cobb, Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro Journal of Biological Chemistry. ,vol. 268, pp. 5097- 5106 ,(1993) , 10.1016/S0021-9258(18)53507-9
A M Friedlander, Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. Journal of Biological Chemistry. ,vol. 261, pp. 7123- 7126 ,(1986) , 10.1016/S0021-9258(17)38364-3
W. Gregory Alvord, Kenneth D. Paull, Mary Jane McWilliams, Larry V. Rubinstein, Anne Monks, Adi F. Gazdar, Herbert K. Oie, Helmut Zarbl, Helmut Zarbl, Han Mo Koo, George F. Vande Woude, Marcia Gray-Goodrich, Andrei M Mikheev, Andrei M Mikheev, Enhanced sensitivity to 1-β-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes Cancer Research. ,vol. 56, pp. 5211- 5216 ,(1996)
Monica S. Murakami, George F. Vande Woude, Mechanisms of Xenopus oocyte maturation Methods in Enzymology. ,vol. 283, pp. 584- 600 ,(1997) , 10.1016/S0076-6879(97)83046-7
Stephen H Leppla, Production and purification of anthrax toxin. Methods in Enzymology. ,vol. 165, pp. 103- 116 ,(1986) , 10.1016/S0076-6879(88)65019-1
P C Hanna, J C Milne, R J Collier, D Furlong, J S Wall, Anthrax protective antigen forms oligomers during intoxication of mammalian cells. Journal of Biological Chemistry. ,vol. 269, pp. 20607- 20612 ,(1994) , 10.1016/S0021-9258(17)32036-7
Sam J. Mansour, Katheryn A. Resing, Julian M. Candi, April S. Hermann, Jason W. Gloor, Keri R. Herskind, Markus Wartmann, Roger J. Davis, Natalie G. Ahn, Mitogen-Activated Protein (MAP) Kinase Phosphorylation of MAP Kinase Kinase: Determination of Phosphorylation Sites by Mass Spectrometry and Site-Directed Mutagenesis Journal of Biochemistry. ,vol. 116, pp. 304- 314 ,(1994) , 10.1093/OXFORDJOURNALS.JBCHEM.A124524
C Pezard, P Berche, M Mock, Contribution of individual toxin components to virulence of Bacillus anthracis. Infection and Immunity. ,vol. 59, pp. 3472- 3477 ,(1991) , 10.1128/IAI.59.10.3472-3477.1991