Cerebral ischaemia induced by bilateral carotid occlusion in spontaneously hypertensive rats

摘要: Abstract Following bilateral carotid occlusion in spontaneously hypertensive rats (SHR), the supratentorial tissue lactate and lactate/pyruvate (L/P) ratio increased ATP concomitantly decreased at 1 hr, although infratentorial L/P by a lesser extent remained unchanged. At 6 increase anaerobic metabolites decrease was greater than hr. Similarly, further this time. Arterial pCO 2 correlated with below range of 20 m M /kg more highly 8 /kg. Above each these values, there no correlation compartment an opposite trend compartment. , determined hourly animals without additional anaesthesia, fell immediately after unchanged or for next This followed gradual rise close to exceeding control level. The present results may suggest that SHR causes marked ischaemic change tissues is time-related. On other hand, it metabolic impairment certain period time (at least hr more), had elapsed. late-occurring changes seems due oedema which caused either haemodynamic derangements mechanical compression brain stem. Spontaneous hyperventilation, reflected as hypocapnia, might be activation stem respiratory centre stimuli CSF lactic acidosis originating from accumulation. When energy deprivation developed following occlusion, hyperventilation tended disappear even insufficiency developed. relationship between ventilation metabolism discussed.