Prostaglandins and steroidogenesis in isolated bovine adrenal cells

摘要: Abstract In bovine adrenal cortex cells, dispersed without preferential loss of we investigated (1) whether endogenous prostaglandins (PGs) are involved in ACTH-induced steroido-genesis, arid (2) the steroidogenic effects PGs and PG analogs. Free cells produced considerable amounts PGE2, whereas only minute quantities PGF2α PGA1 were synthesized. PGE2 synthesis, however, was not significantly increased when ACTH elicited a response free cells. High concentrations PG-synthesis inhibitors such as indomethacin affected both synthesis steroidogenesis, intermediate (10−6 M) inhibited production aldosterone even after cAMP cortisol to had returned normal values. It is concluded that link acute mechanism action trophic hormones which involved. Of prostanoid structures, E series most potent stimulating agents production, although less active than ACTH. On other hand, induced an ACTH-like synthesis. structures effect on production. suggested pathological circumstances, regulates increases