Enhanced Expression of Inducible Nitric Oxide Synthase and Nitrotyrosine in Gastric Mucosa of Gastric Cancer Patients

摘要: Recent studies (K. Komoto et al. , Am. J. Gastroenterol., 93: 1271–1276, 1998) have shown that Helicobacter pylori infection is associated with gastric cancer. However, the mechanism of H. in carcinogenesis has not been clarified. leads to a sustained production reactive nitrogen species may contribute cause DNA damage. In this study, we examined expression inducible nitric oxide synthase (iNOS) and nitrotyrosine mucosa. The iNOS was by immunohistochemistry 93 patients who initially underwent biopsies between 1975 1992. Thirty-four individuals were later found cancer at least 2 years after initial (group A). other 59 subjects no evidence during long-term follow-up. Fifty-one these positive for B), eight negative C). mucosa significantly higher -positive groups A B than -negative group C. Among patients, B. These results suggest high infected