Activated protein C resistance testing for factor V Leiden.

摘要: Activated protein C resistance assays can detect factor V Leiden with high accuracy, depending on the method used. Factor Xa inhibitors such as rivaroxaban and direct thrombin including dabigatran, argatroban, bivalirudin cause falsely normal results. Lupus anticoagulants incorrect results in most current assays. Assays that include dilution into V-deficient plasma are needed to avoid interference from deficiencies or elevations, which arise a wide variety of conditions warfarin, liver dysfunction, pregnancy. The pros cons currently available discussed.