Foam cell replication and smooth muscle cell apoptosis in human saphenous vein grafts
作者： M.M. KOCKX , B.A. CAMBIER , H.E. BORTIER , G.R. DE MEYER , S.C. DECLERCQ
DOI: 10.1111/J.1365-2559.1994.TB01355.X
关键词:
摘要: Occlusion of saphenous vein grafts is a major problem after coronary artery bypass grafting. Segments occluded and suboccluded implanted aortocoronary were obtained during re-intervention grafting in 47 patients yielding total 80 grafts. The studied by immunohistochemistry for smooth muscle cells (alpha-SMC actin), macrophages (HAM56), cell replication (PCNA, Ki-67) transmission scanning electronmicroscopy (TEM, SEM). In 81% the examined (sub)occlusion was due to myo-intimal thickening an associated luminal accumulation foam mural thrombi. constantly found at site within part adherent Transmission demonstrated phagocytosis platelets platelet fragments cells. A significant fraction nuclear immunoreactivity Ki-67 PCNA. composed lying fibrous tissue matrix. surrounded prominent basal lamina showed ultrastructural features apoptosis. Our results support hypothesis that lipid rich monocytes set up mechanism formation human transformation myointimal towards fibrous, poor intimal could be induced progressive loss through
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