Decreased SFRP2 expression is associated with intermediate and poor karyotypes in de novo acute myeloid leukemia.
作者： Xiang-Mei Wen , Cui An , Ji-Chun Ma , Zhao-Qun Deng , Jiang Lin
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摘要: Dysregulation of secreted frizzled-related protein 2 (SFRP2) has been found in various cancers. However, it is little known about the pattern SFRP2 expression acute myeloid leukemia (AML). This study was aimed to analyze status gene AML patients and explore its clinical significance using real-time quantitative PCR (RQ-PCR). The level significantly decreased compared controls (P 0.05). increased after CR initial diagnosis (P<0.05). These findings suggest that associated with intermediate/poor karyotypes detection may be helpful disease monitoring CN-AML.
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