摘要: Eine reduzierte Aktivitat des endogenen fibrinolytischen Systems tragt durch Ablagerung von Mikrothromben in die Gefaswand zur Atherogenese bei und fuhrt intraluminale Thromben zu Komplikationen der Atherosklerose wie den akuten koronaren Syndromen. Bei Regulation Fibrinolyse spielt das Endothel eine wichtige Rolle. Die vorliegende Ubersichtsarbeit stellt zuerst Bestandteile ihr Zusammenspiel vor betrachtet dann bisher vorliegenden Befunde Rolle Renin-Angiotensin-Systems, Kallikrein-Kinin-Systems Typ 2-Diabetes mellitus Fibrinolyse. Untersuchungen mit transgenen Knock-out-Tiermodellen haben wesentlich zum Verstandnis Interaktion zwischen dem System beigetragen werden im einzelnen vorgestellt. Schlieslich sich aus Befunden ergebenden therapeutischen Moglichkeiten diskutiert.
springer.com
sci-hub.se 参考文章(35)
D Smith, M Gilbert, WG Owen, Tissue plasminogen activator release in vivo in response to vasoactive agents. Blood. ,vol. 66, pp. 835- 839 ,(1985) , 10.1182/BLOOD.V66.4.835.835
Ardaillou R, Angiotensin II receptors Journal of The American Society of Nephrology. ,vol. 10, pp. 30- 39 ,(1999)
E. Cagliero, T. Roth, S. Roy, M. Maiello, M. Lorenzi, Expression of genes related to the extracellular matrix in human endothelial cells. Differential modulation by elevated glucose concentrations, phorbol esters, and cAMP. Journal of Biological Chemistry. ,vol. 266, pp. 14244- 14250 ,(1991) , 10.1016/S0021-9258(18)98674-6
Hiroyuki Matsuno, Osamu Kozawa, Masayuki Niwa, Shigeru Ueshima, Osamu Matsuo, Désiré Collen, Toshihiko Uematsu, None, Differential Role of Components of the Fibrinolytic System in the Formation and Removal of Thrombus Induced by Endothelial Injury Thrombosis and Haemostasis. ,vol. 81, pp. 601- 604 ,(1999) , 10.1055/S-0037-1614532
Robert A. Wright, Andrew D. Flapan, K.George M.M. Alberti, Christopher A. Ludlam, Keith A.A. Fox, Effects of captopril therapy on endogenous fibrinolysis in men with recent, uncomplicated myocardial infarction Journal of the American College of Cardiology. ,vol. 24, pp. 67- 73 ,(1994) , 10.1016/0735-1097(94)90543-6
Allen D. Hamdan, William C. Quist, Jennifer B. Gagne, Edward P. Feener, Angiotensin-Converting Enzyme Inhibition Suppresses Plasminogen Activator Inhibitor-1 Expression in the Neointima of Balloon-Injured Rat Aorta Circulation. ,vol. 93, pp. 1073- 1078 ,(1996) , 10.1161/01.CIR.93.6.1073
Douglas E Vaughan, Jean-Lucien Rouleau, Paul M Ridker, J Malcolm O Arnold, Francis J Menapace, Marc A Pfeffer, None, Effects of Ramipril on Plasma Fibrinolytic Balance in Patients With Acute Anterior Myocardial Infarction Circulation. ,vol. 96, pp. 442- 447 ,(1997) , 10.1161/01.CIR.96.2.442
David J. Schneider, P. Marlene Absher, Michael A. Ricci, Dependence of Augmentation of Arterial Endothelial Cell Expression of Plasminogen Activator Inhibitor Type 1 by Insulin on Soluble Factors Released From Vascular Smooth Muscle Cells Circulation. ,vol. 96, pp. 2868- 2876 ,(1997) , 10.1161/01.CIR.96.9.2868
M. Medvešcek, D. Keber, M. Stegnar, A. Borovnicar, Plasminogen activator inhibitor I response to a carbohydrate meal in obese subjects Fibrinolysis and Proteolysis. ,vol. 4, pp. 89- 90 ,(1990) , 10.1016/0268-9499(90)90371-P
M. Maiello, D. Boeri, F. Podesta, E. Cagliero, M. Vichi, P. Odetti, L. Adezati, M. Lorenzi, Increased Expression of Tissue Plasminogen Activator and Its Inhibitor and Reduced Fibrinolytic Potential of Human Endothelial Cells Cultured in Elevated Glucose Diabetes. ,vol. 41, pp. 1009- 1015 ,(1992) , 10.2337/DIAB.41.8.1009