Dietary resveratrol administration increases MnSOD expression and activity in mouse brain.

摘要: trans-Resveratrol (3,4',5-trihydroxystilbene; RES) is of interest for its reported protective effects in a variety pathologies, including neurodegeneration. Many these properties have been attributed to the ability RES reduce oxidative stress. In vitro studies shown an increase antioxidant enzyme activities following exposure RES, upregulation mitochondrial superoxide dismutase, that capable reducing both stress and cell death. We sought determine if similar endogenous enzymes observed with treatment vivo. Three separate modes delivery were utilized; standard diet, high fat diet through subcutaneous osmotic minipump. given proved be effective elevating capacity brain resulting MnSOD protein level (140%) activity (75%). The was not due substantial proliferation mitochondria, as induced 10% abundance (Citrate Synthase activity). potential neuroprotective well established, we demonstrate dietary able expression this