White matter tracts for the trafficking of neural progenitor cells characterized by cellular MRI and immunohistology: the role of CXCL12/CXCR4 signaling.

摘要: White matter tracts are important for the trafficking of neural progenitor cells (NPCs) in both normal and pathological conditions, but underlying mechanism is not clear. The directionality white advantageous molecules or to distribute over a long distance, this feature unlikely solely responsible efficient migration. present study hypothesizes that migration NPCs into under influences neurochemical attraction—CXCL12/CXCR4 signaling, major targeted NPCs. To test view, investigated effects CXCL12 administration corpus callosum (CC) on migratory behavior transplanted A living animal tracking platform based MRI magnetic cell labeling technique was employed. were magnetically labeled then at right end CC. infused continuously left end. Migration monitored repeatedly 7-day course using 3D gradient echo T2*-weighted imaging. It found that, induced migrate up 1,881 μm from graft whereas spontaneous mere 200 μm. nine times as speed. results indicate CXCL12/CXCR4 signaling may be via which efficiently along tracts. also presents potential strategy facilitating NPC therapy brain disorders.