Tussive effect of a fentanyl bolus

摘要: The aim of this study was to investigate the incidence pre-induction coughing, after an iv bolus fentanyl. sample 250 ASA physical status I-II patients, scheduled for various elective surgical procedures. first 100 were randomly allocated recieve 1.5 μg · kg−1 fentanyl via a peripheral venous cannula (Group 1), or equivalent volume saline 2). Twenty-eight per cent patients who received fentanyl, but none given saline, coughed within one minute (P < 0.0001). second 150 then assigned three equal pretreatment groups. Group 3 0.01 kg-1 atropine before Groups 4 and 5 0.2 morphine im, 7.5 mg midazolam po, respectively, hour Thirty in 3, 6% 4, 40% 5, had cough response Fentanyl, when through cannula, provoked considerable proportion patients. This not altered by premedication with midazolam, reduced 0.01). Coughing upon induction anaesthesia is undesirable some stimulation unpremedicated may be clinical importance.