Role of ZnS shell on stability, cytotoxicity, and photocytotoxicity of water-soluble CdSe semiconductor quantum dots surface modified with glutathione

摘要: Biomedical applications of quantum dots (QDs) have become a subject considerable concern in the past few decades. The present study examines stability and cytotoxicity two QDs systems cell culture medium the presence absence thin layer ZnS shell. were built from core, CdSe QDs, surface modified with glutathione (GSH), named CdSe∼GSH CdSe/ZnS∼GSH. Our results demonstrated that 0.7 nm ZnS shell played significant role CdSe/ZnS~GSH supplemented (RPMI). Also, improvement physicochemical properties core was shown by maintaining their spectroscopic characteristics RPMI due to wide band gap Both showed insignificant reduction viability HFB-4 or MCF-7 lines dark which attributed effective GSH coating. Following photoirradiation with low laser power (irradiance 10 mW cm -2 ), CdSe~GSH showed a significant decrease after 60 min irradiation may result detachment GSH molecules. Under the same condition, insignificant 2 h incubation strong binding between coatings. It can be concluded significantly improved encapsulation a thin shell whereas their photo-cytotoxicity are highly dependent on modification.