Concentrations of Trace Elements in Hemodialysis Patients: A Prospective Cohort Study

摘要: Background Low concentrations and excessive of trace elements have been commonly reported in hemodialysis patients, but available studies several important limitations. Study Design Random sample patients drawn from a prospective cohort. Setting & Participants 198 incident treated 3 Canadian centers. Measurements We used mass spectrometry to measure plasma the 25 at baseline, 6 months, 1 year, 2 years following enrollment focused on low zinc, selenium, manganese lead, arsenic, mercury; other 19 were as exploratory analyses. based 5th 95th percentile healthy reference populations. Results At all 4 occasions, uncommon study participants (≤5.1%, ≤1.8%, and ≤0.9% for manganese, respectively) substantial proportion had that exceeded (≥65.2%, ≥74.2%, and ≥19.7%, respectively). Almost lead above time points. The with arsenic exceeding was relatively constant over (9.1%-9.8%); mercury varied between 15.2% 29.3%. platinum, tungsten, beryllium common (>50%), cobalt, vanadium, cadmium, barium, antimony, nickel, molybdenum, chromium concentrations. Conclusions There no evidence or exist most contemporary patients. Some concentrations, common. These findings require further investigation.