Dynamics of anti-M antibody response in a mouse model following intranasal infection with group A Streptococcus M-18.
作者： Paul Gladstone , George Varghese , K N Brahmadathan
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摘要: Dynamics of anti-M antibody response following intranasal infection with group A Streptococcus (GAS) M-18 were investigated in a Swiss albino mouse model. Mice arranged three groups inoculated intranasally 2.0 × 107 c.f.u. ml−1 GAS on 1, 2 alternate and 3 days. Plasma collected from the retro-orbital plexus was tested for antibodies by an in-house indirect ELISA. The titres plasma samples varied 1 : 8 to 1024 day dose, 4 256 dose 128 dose. Peak seen 42 or 56 all cases had declined 84. can thus serve as useful animal model study different aspects type-specific immune responses against disease when designing candidate streptococcal vaccines.
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