Adenoviral expression vectors

摘要: The present invention provides a recombinant adenovirus vector characterized by the partial or total deletion of adenoviral E2B function and having an expression cassette containing heterologous sequence encoding protein interest inserted into E1 region. Such vectors are designed to reduce eliminate occurrence replication competent contamination. Additionally, may contain one more regulatory elements capable increasing and/or reducing viral proteins. reduction in proteins reduces cytotoxicty immunogenicity when administered vivo. Transformed production host cells method producing gene therapy also included within scope this invention.