Copy number variation of glyoxalase I
作者： Alaa Shafie , Mingzhan Xue , Paul J. Thornalley , Naila Rabbani
DOI: 10.1042/BST20140011
关键词:
摘要: The glyoxalase I gene GLO1 is a hotspot for copy number variation in the human and mouse genomes. additional copies are often functional, giving rise to 2–4-fold increased expression activity. prevalence of increase population appears be approximately 2% may linked risk obesity, diabetes aging. Increased has been found tumour cell lines primary tumours. minimum common region was 1 Mb it contained seven other genes. generally being associated with protein multidrug resistance cancer chemotherapy. Glo1 duplication genome within 0.5 duplicated DNA. It claimed anxiety phenotypes, but related discordant findings have doubted association further investigation required. Abbreviations: CNV, variation; GABAA, γ-aminobutyric acid A; Glo, glyoxalase; MDR, resistance; MG, methylglyoxal
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