Regulation of Cerebral Autoregulation by Carbon Dioxide

摘要: Cerebral autoregulation describes a mechanism that maintains cerebral blood flow stable despite fluctuating perfusion pressure. Multiple nonperfusion pressure processes also regulate perfusion. These mechanisms are integrated. The effect of the interplay between carbon dioxide and on circulation has not been specifically reviewed. On basis published data speculation aspects without supportive data, authors offer conceptualization delineating regulation by dioxide. conclude hypercapnia causes plateau to progressively ascend, rightward shift lower limit, leftward upper limit. Conversely, hypocapnia results in shifting flows, unremarkable change unclear It is emphasized sound understanding both limitations dynamic integrated nature fosters safer clinical practice.