What Is the Present Pathogenetic Concept of Glaucomatous Optic Neuropathy

摘要: Glaucomatous optic neuropathy implies loss of neural tissue, activation glial cells, tissue remodeling, and change blood flow. The flow reduction is not only secondary but has a primary component. Activation astrocytes leads to an altered microenvironment. An unstable ocular perfusion, either due IOP fluctuation or disturbed autoregulation (due vascular dysregulation syndrome) mild reperfusion injury. superoxide (O2−) anion produced in the mitochondria axons, fuses with nitric oxide (NO) diffusing from astrocytes, leading damaging peroxynitrite (ONOO−). It possible that diffusion endothelin metalloproteinases surrounding nerve head local vasoconstriction thereby increases risk for venous occlusion weakens blood–brain barrier, which extreme situations results splinter hemorrhages. Activated retinal can be visualized clinically. involvement pathogenesis glaucomatous may explain why women, as well Japanese, suffer more often normal-tension glaucoma.