Analysis of endocrine disruptors, pharmaceuticals, and personal care products in water using liquid chromatography/tandem mass spectrometry.
作者： Brett J. Vanderford , Rebecca A. Pearson , David J. Rexing , Shane A. Snyder
DOI: 10.1021/AC034210G
关键词:
摘要: A method has been developed for the trace analysis of 27 compounds from a diverse group pharmaceuticals, steroids, pesticides, and personal care products. The employs solid-phase extraction (SPE) liquid chromatography/tandem mass spectrometry (LC/MS/MS), using electrospray ionization (ESI) in both positive negative modes atmospheric pressure chemical mode. Unlike many previous methods, single SPE procedure 1 L water coupled to simple LC is used all modes. Instrument detection limits most were below 1.0 pg on column with reporting ng/L water. Recoveries deionized greater than 80%. Sulfuric acid was found be preferred sample preservative, structures MS/MS product ions are proposed. Matrix effects waters high content treated municipal effluent observed ESI discussed paper.
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