Shape optimization of pulsatile ventricular assist devices using FSI to minimize thrombotic risk

摘要: In this paper we perform shape optimization of a pediatric pulsatile ventricular assist device (PVAD). The simulation is carried out using fluid---structure interaction (FSI) modeling techniques within computational framework that combines FEM for fluid mechanics and isogeometric analysis structural modeling. PVAD FSI simulations are performed under realistic conditions (i.e., flow speeds, pressure levels, boundary conditions, etc.), account the air, blood, thin membrane separating two subdomains. study designed to reduce thrombotic risk, major clinical problem in PVADs. Thrombotic risk quantified terms particle residence time blood chamber. Methods compute context moving spatial domains presented companion published same issue (Comput Mech, doi: 10.1007/s00466-013-0931-y , 2013). surrogate management framework, derivative-free pattern search method relies on surrogates increased efficiency, employed work. For shown here, used define suitable cost or objective function, while four adjustable design parameters geometry. FSI-based implemented parallel computing environment, deployed with minimal user intervention. Using five SEARCH/POLL steps scheme identifies significantly better throughput efficiency than original device.