Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-γ and macrophage colony-stimulating factor
作者： Yoshinori Mita , Kunio Dobashi , Yasuo Shimizu , Tsugio Nakazawa , Masatomo Mori
DOI: 10.1016/S0165-2478(01)00241-3
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摘要: Abstract Human Toll-like receptor 2 (TLR2) and TLR4 are recently identified receptors. was shown to be the main protein involved in recognizing Gram-negative bacteria, whereas TLR2 is apparently key factor responses other types of microbial pathogens. We examined regulations surface expressions human peripheral blood monocytes by interferon-γ (IFN-γ) macrophage colony-stimulating (M-CSF). IFN-γ up-regulated both TLR4, but enhanced expression, on more than that TLR2. On hand, M-CSF expression monocytes, with no change ratio TLR2/TLR4 expression. These results indicate enhances receptors response bacteria those pathogens, same manner as
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