Cortical Neurogensis in Adult Brains After Focal Cerebral Ischemia

摘要: Stroke ranks as the most common reason to disable adult patients and second for mortality. Current treatment of ischemic stroke through trombolysis or trombectomy aims initiate successful early reperfusion into penumbral tissue. If it is promptly properly performed, may reverse cascade rescue penumbra from being further recruited infarct thus improve neurological outcome. Once formed, no currently available enhance post brain repair. Under physiological conditions, neurons in cerebral cortex are terminally differentiated shortly after birth. The phenomenon that a cavity usually forms elicits histological postulation brains do not have capacity generate new pathological insults i.e., stroke. Nevertheless, recovery various degrees commonly seen with clinical improvement starts week onset last up 18 months. underlying mechanisms this only sparsely understood, although many factors been suggested such deafferentiating, activity-dependent synaptic changes, altered membrane excitability, outgrowth axons dendrites.