Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients

摘要: Next to α-synuclein deposition, microglial activation is a prominent pathological feature in the substantia nigra (SN) of Parkinson’s disease (PD) patients. Little known, however, about different phenotypes microglia and how they change during progression, SN or another brain region, like hippocampus (HC), which implicated dementia depression, important non-motor symptoms PD. We studied HC established PD patients (Braak stage 4–6), matched controls 0) incidental Lewy Body (iLBD) cases 1–3) that are considered prodromal state As recent experimental studies suggested toll-like receptor 2 (TLR2) mediates triggered activation, we also whether TLR2 expression indeed related pathology iLBD A clear pathology-related increase amoeboid was present Also, morphologically primed/reactive cells, profound were apparent iLBD, but not PD, cases, indicative an early activational response pathology. Moreover, differentially expressed between HC, consistent with region-specific pattern activation. In conclusion, regional changes phenotype indicate may play role microglial-mediated responses could be for progression.