Iron deficiency is associated with higher mortality in patients undergoing cardiac surgery: a prospective study.
作者： Julian Rössler , Felix Schoenrath , Burkhardt Seifert , Alexander Kaserer , Gabriela H. Spahn
DOI: 10.1016/J.BJA.2019.09.016
关键词:
摘要: Abstract Background Iron deficiency is frequent in patients undergoing cardiac surgery. The relevance of iron deficiency, however, ill defined. Therefore, our study aimed to investigate the impact (ferritin Methods In this prospective observational study, 730 elective surgery were assigned into four groups according their status and anaemia. Mortality, serious adverse events (SAEs), major cerebrovascular (MACCEs), allogenic blood transfusion requirements, length hospital stay assessed during a 90-day follow-up period. effect on these outcomes was first calculated models adjusting for anaemia only, followed by two multivariate either EuroSCORE II or any possible confounders. Results presence Conclusions Preoperative Clinical trial registration NCT02031289.
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I. Egll, M. Cogswell, E. McLean, B. de Benoist, Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia. Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia.. ,(2008)
Tarun Mehra, Burkhardt Seifert, Silvina Bravo-Reiter, Guido Wanner, Philipp Dutkowski, Tomas Holubec, Rudolf M. Moos, Jörk Volbracht, Markus G. Manz, Donat R. Spahn, Implementation of a patient blood management monitoring and feedback program significantly reduces transfusions and costs Transfusion. ,vol. 55, pp. 2807- 2815 ,(2015) , 10.1111/TRF.13260
Tomas Ganz, Elizabeta Nemeth, Hepcidin and iron homeostasis Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. ,vol. 1823, pp. 1434- 1443 ,(2012) , 10.1016/J.BBAMCR.2012.01.014
J. P. Isbister, The three‐pillar matrix of patient blood management Isbt Science Series. ,vol. 10, pp. 286- 294 ,(2015) , 10.1111/VOXS.12135
Stefan D Anker, Josep Comin Colet, Gerasimos Filippatos, Ronnie Willenheimer, Kenneth Dickstein, Helmut Drexler, Thomas F Lüscher, Boris Bart, Waldemar Banasiak, Joanna Niegowska, Bridget-Anne Kirwan, Claudio Mori, Barbara von Eisenhart Rothe, Stuart J Pocock, Philip A Poole-Wilson, Piotr Ponikowski, None, Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency The New England Journal of Medicine. ,vol. 361, pp. 2436- 2448 ,(2009) , 10.1056/NEJMOA0908355
Matthew Hung, Erik Ortmann, Martin Besser, Pedro Martin-Cabrera, Toby Richards, Marcus Ghosh, Fiona Bottrill, Timothy Collier, Andrew A Klein, A prospective observational cohort study to identify the causes of anaemia and association with outcome in cardiac surgical patients Heart. ,vol. 101, pp. 107- 112 ,(2015) , 10.1136/HEARTJNL-2014-305856
AA Klein, TJ Collier, MS Brar, C Evans, G Hallward, SN Fletcher, T Richards, Association of Cardiothoracic Anaesthetists (ACTA), RP Alston, H Pauli, A Vijayan, A Pai, D Krahne, D Glasgow, P Fernandez Jimenez, S Agarwal, A Kelleher, A Cohen, N Balani, D Helme, The incidence and importance of anaemia in patients undergoing cardiac surgery in the UK – the first Association of Cardiothoracic Anaesthetists national audit† Anaesthesia. ,vol. 71, pp. 627- 635 ,(2016) , 10.1111/ANAE.13423
Pascale Piednoir, Nicolas Allou, Fathi Driss, Dan Longrois, Ivan Philip, Carole Beaumont, Philippe Montravers, Sigismond Lasocki, Preoperative iron deficiency increases transfusion requirements and fatigue in cardiac surgery patients: a prospective observational study. European Journal of Anaesthesiology. ,vol. 28, pp. 796- 801 ,(2011) , 10.1097/EJA.0B013E32834AD97B
Piotr Ponikowski, Adriaan A. Voors, Stefan D. Anker, Héctor Bueno, John G. F. Cleland, Andrew J. S. Coats, Volkmar Falk, José Ramón González-Juanatey, Veli-Pekka Harjola, Ewa A. Jankowska, Mariell Jessup, Cecilia Linde, Petros Nihoyannopoulos, John T. Parissis, Burkert Pieske, Jillian P. Riley, Giuseppe M. C. Rosano, Luis M. Ruilope, Frank Ruschitzka, Frans H. Rutten, Peter van der Meer, , , 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European Journal of Heart Failure. ,vol. 18, pp. 891- 975 ,(2016) , 10.1002/EJHF.592
Vojtech Melenovsky, Jiri Petrak, Tomas Mracek, Jan Benes, Barry A. Borlaug, Hana Nuskova, Tomas Pluhacek, Jaroslav Spatenka, Jana Kovalcikova, Zdenek Drahota, Josef Kautzner, Jan Pirk, Josef Houstek, Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. European Journal of Heart Failure. ,vol. 19, pp. 522- 530 ,(2017) , 10.1002/EJHF.640