Dimenhydrinate Decreases Vomiting After Strabismus Surgery in Children

摘要: Dimenhydrinate, an H1-receptor antagonist, has been used to both prevent and treat postoperative vomiting (POV) in children for several decades. However, its effectiveness POV after strabismus surgery remains anecdotal. This study was designed determine the side effects of dimenhydrinate prevention surgery. Eighty ASA physical status I or II children, ages 1-12 yr inclusive, who were undergoing surgery, prospectively randomly allocated receive either 0.5 mg/kg intravenously (n = 40) placebo at induction anesthesia. The incidence times arousal (and discharge from recovery room hospital) recorded postoperatively a double blinded manner. For 24 h hospital, all emetic episodes medications given by parents. Demographic data did not differ between groups. Children received had significantly less inhospital (10%) overall (30%) than those (in-hospital 38%, P < 0.008; 65%, 0.003). hospital two Dimenhydrinate (0.5 mg/kg) is effective, safe, inexpensive antiemetic It reduces associated with prolonged sedation other adverse effects.