Metabolism of progesterone by rat testicular homogenates. I. Isolation and identification of metabolites.

摘要: Homogenates of rat testicular tissue have been incubated with progesterone- 4-14C and certain the metabolites identified. When small ratios substrate to were used, there was usually a large conversion testosterone-14C (30–35%). Much smaller amounts Δ4-androstene-3,17-dione 17-hydroxy-Δ4-pregnene-3,20-dione found. Labeled 16α-hydroxy-δ4-pregnene-3, 20-dione 17,20α-dihydroxy-Δ4-pregnen-3- one produced in yields. Substantial conversions (8–40%) 5α-androstane-3α,17β- diol These results indicate that testosterone is principal androgen homogenates, that, at least vitro, testis further metabolizes significant by reduction ring A. (Endocrinology 78: 460, 1966)