Genetic diversity of disease-associated loci in Turkish population.

摘要: Many consortia and international projects have investigated the human genetic variation of a large number ethno-geographic groups. However, populations with peculiar features, such as Turkish population, are still absent in publically available datasets. To explore predisposition to health-related traits we analyzed 34 genes associated different (for example, lipid metabolism, cardio-vascular diseases, hormone cellular detoxification, aging energy metabolism). We observed relevant differences between population non-European ancestries (that is, Africa East Asia) some AGT, APOE, CYP1B1, GNB3, IL10, IL6, LIPC PON1). As most complex highly polygenic, developed polygenic scores diversity respect other This approach showed significant ancestries, well Northern European individuals. last finding is agreement structure Middle populations, may also agree epidemiological evidences about health disparities communities countries.