摘要: Thirty years after its discovery, the hepatitis E virus (HEV) continues to represent a major public health problem in developing countries. In developed countries, it has emerged as significant cause of non-travel-associated acute hepatitis. HEV infects wide range mammalian species and key reservoir worldwide appears be swine. Genomic sequence similarity between some human genotypes swine strains been identified we know that humans can acquire infection from animals. Although for most part clinical course is asymptomatic or mild, risk serious disease exists pregnant women those with chronic liver disease. addition, there are data on threat infections immunocompromised patients. Beyond management exposure by measures, recent support active immunisation prevent E, highlighting need vaccination programmes. Here review current knowledge HEV, epidemiology, prevention