Adhesion of mouse fibroblasts on hexamethyldisiloxane surfaces with wide range of wettability.

摘要: Surface wettability is an important physicochemical property of biomaterials, and it would be more helpful for understanding this if a wide range are employed. This study focused on the effect surface fibroblast adhesion over using single material without changing topography. Plasma polymerization with hexamethyldisiloxane followed by oxygen (O2)-plasma treatment was employed to modify surfaces. The water contact angle sample surfaces varied from 106 degrees (hydrophobicity) almost 0 (super-hydrophilicity). O2 functional groups were introduced polymer during O2-plasma treatment. cell attachment confirmed that hydrophilic surface, fibroblasts adhered in initial stage includes super-hydrophilic Cells spread much widely than hydrophobic There no significant difference proliferation, but spreading greater fibronectin adsorbed while albumin dominated competing mode. These findings suggest importance biomaterials spreading. degree should taken into account when new biomaterial