A new role of Klumpfuss in establishing cell fate during the GMC asymmetric cell division
作者： Hugo Gabilondo , María Losada-Pérez , Ignacio Monedero , Arturo Torres-Herráez , Isabel Molina
DOI: 10.1007/S00441-014-1965-Y
关键词:
摘要: Studies in the Drosophila embryonic NB4-2 lineage have suggested that transcription factor Klumpfuss (Klu) functions within neuroblast lineages to differentiate between identities of two adjacent ganglion mother cells (GMCs). However, because limited markers available, these observations been made only for lineage. Recent findings placed this vanguard neural stem cell biology by demonstrating Klu is necessary larval growth and self-renewal. Here, we studied role klu an incipient model order address basic mechanisms specification: Va system. None previously reported roles satisfactorily explain our observations. Unexpectedly, lineage, differentiating fates neurons born from a unique GMC; mutants produce B-type cells, rather than one (Notch-OFF) A-type (Notch-ON) cell. Additionally, results demonstrate operates GMC and/or newly neuron, but not neuroblast. Unlike neuroblasts which executor Notch signaling, found does lie downstream pathway division context.
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K White, M. Grether, J. Abrams, L Young, K Farrell, H Steller, Genetic control of programmed cell death in Drosophila Science. ,vol. 264, pp. 677- 683 ,(1994) , 10.1126/SCIENCE.8171319
Jocelyn A. McDonald, Miki Fujioka, Joanne P. Odden, James B. Jaynes, Chris Q. Doe, Specification of motoneuron fate in Drosophila: Integration of positive and negative transcription factor inputs by a minimal eve enhancer Journal of Neurobiology. ,vol. 57, pp. 193- 203 ,(2003) , 10.1002/NEU.10264
Anke Suska, Irene Miguel-Aliaga, Stefan Thor, Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues. Developmental Biology. ,vol. 353, pp. 72- 80 ,(2011) , 10.1016/J.YDBIO.2011.02.015
Hugo Gabilondo, María Losada-Pérez, Delia del Saz, Isabel Molina, Yolanda León, Inmaculada Canal, Laura Torroja, Jonathan Benito-Sipos, A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. Mechanisms of Development. ,vol. 128, pp. 208- 221 ,(2011) , 10.1016/J.MOD.2011.01.002
Chris Q. Doe, Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system. Development. ,vol. 116, pp. 855- 863 ,(1992) , 10.1242/DEV.116.4.855
X Yang, S Bahri, T Klein, W Chia, Klumpfuss, a putative Drosophila zinc finger transcription factor, acts to differentiate between the identities of two secondary precursor cells within one neuroblast lineage. Genes & Development. ,vol. 11, pp. 1396- 1408 ,(1997) , 10.1101/GAD.11.11.1396
Christian Berger, Heike Harzer, Thomas R. Burkard, Jonas Steinmann, Suzanne van der Horst, Anne-Sophie Laurenson, Maria Novatchkova, Heinrich Reichert, Juergen A. Knoblich, FACS Purification and Transcriptome Analysis of Drosophila Neural Stem Cells Reveals a Role for Klumpfuss in Self-Renewal Cell Reports. ,vol. 2, pp. 407- 418 ,(2012) , 10.1016/J.CELREP.2012.07.008
Q. Xiao, H. Komori, C.-Y. Lee, klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division Development. ,vol. 139, pp. 2670- 2680 ,(2012) , 10.1242/DEV.081687
José A. Campos-Ortega, Thomas Klein, klumpfuss, a Drosophila gene encoding a member of the EGR family of transcription factors, is involved in bristle and leg development Development. ,vol. 124, pp. 3123- 3134 ,(1997) , 10.1242/DEV.124.16.3123