Substituted indolines which inhibit receptor tyrosine kinases
作者： Armin Heckel , Jacobus Van Meel , Rainer Walter , Frank Hilberg , Norbert Redemann
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摘要: Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well proliferation endothelial cells various tumor cells. Exemplary are: (a) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-ethoxycarbonyl-2-indolinone, (b) 3-Z-[(1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-carbamoyl-2-indolinone, (c) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-metboxycarbonyl-2-indolinone.
lens.org参考文章(7)
Armin Heckel, Jacobus C. A. Van Meel, Rainer Walter, Robert Redemann, Wolfgang Grell, Substituted indolinones having an inhibiting effect on kinases and cycline/cdk complexes ,(1999)
Karen Elizabeth Lackey, Robert Walton Mcnutt, Lee Frederick Kuyper, Kimberly Caroline Glennon, 3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors ,(2000)
James Marvin Veal, Karey Elizabeth Lackey, Stephen Vernon Frye, Robert Neil Hunter, Philip Anthony Harris, Stephen Thomas Davis, Duncan Herrick Walker, Scott Howard Dickerson, Michael Joseph Luzzio, Lee Frederick Kuyper, Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threonine kinase inhibitors ,(1998)
Armin Heckel, Rainer Walter, Norbert Redemann, Jakobus Van Meel, Wolfgang Grell, Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel ,(1998)
Li Sun, Gerald McMahon, Peng Cho Tang, 3-(4'-dimethylaminobenzylidenyl)-2-indolinone and analogues thereof for the treatment of disease ,(1996)
Armin Heckel, Jacobus Constantinus Antonius van Meel, Rainer Walter, Frank Himmelsbach, Norbert Redemann, Helmut Wittneben, Wolfgang Grell, Robert Haigh, Indolinones having kinase-inhibiting activity ,(1999)
Armin Heckel, Rainer Walter, Norbert Redemann, Wolfgang Grell, Meel Jacobus C. A. Van, Substituted indolinones, the production thereof and their use as medicaments ,(1999)