Design, synthesis, and biological evaluation of simplified α-Keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase
作者： Thomas H Marsilje , Michael P Hedrick , Joel Desharnais , Ali Tavassoli , Yan Zhang
DOI: 10.1016/S0968-0896(03)00456-5
关键词:
摘要: A series of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues lacking the benzoylglutamate subunit were prepared examined as potential inhibitors glycinamide ribonucleotide transformylase (GAR Tfase) aminoimidazole carboxamide (AICAR Tfase).
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