Photocross-linkable Methacrylated Polypeptides and Polysaccharides for Casting, Injecting, and 3D Fabrication.

摘要: For modern tissue engineering, we need not only develop new hydrogels but also suitable processing methods for them. Polypeptides and polysaccharides are potential candidates because they can be methacrylated, processed before photocross-linking, yielded into with given shape form. In this study, successfully methacrylated collagen, gelatin, hyaluronan, alginate to 30 60% degree of modification. We studied compositions (i.e., precursors) investigate their processability. The precursors collagen gelatin methacrylation exhibited yield stress, shear-thinning properties, fiber-forming capability injecting 3D bioprinting. On the contrary, 30% had properties casting purposes. Our study showed that mechanical corresponded used photocross-linking conditions These results underline importance tunability resulting according specific fabrication method engineering application.