Interleukin-4 (IL-4) pathway.
作者： A. Kelly-Welch , E. M. Hanson , A. D. Keegan
关键词:
摘要: Interleukin-4 (IL-4) is a cytokine produced by T(H)2 type helper T cells and mast cells, basophils, eosinophils. This can elicit many responses, some of which are associated with allergy asthma. Studies long-term cell lines primary have revealed differences in the signaling between these two experimental systems. Understanding important because therapeutic strategies targeting IL-4 its pathways currently being tested to treat
sciencemag.org参考文章(19)
André Gessner, Katja Mohrs, Markus Mohrs, Mast Cells, Basophils, and Eosinophils Acquire Constitutive IL-4 and IL-13 Transcripts during Lineage Differentiation That Are Sufficient for Rapid Cytokine Production Journal of Immunology. ,vol. 174, pp. 1063- 1072 ,(2005) , 10.4049/JIMMUNOL.174.2.1063
Ana L. Mora, Linda M. Stephenson, Ben Enerson, Jeehee Youn, Achsah D. Keegan, Mark Boothby, New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Rα lacking cytoplasmic tyrosines Journal of Immunology. ,vol. 171, pp. 1891- 1900 ,(2003) , 10.4049/JIMMUNOL.171.4.1891
Andrea L. Wurster, Vikki L. Rodgers, Morris F. White, Thomas L. Rothstein, Michael J. Grusby, Interleukin-4-mediated Protection of Primary B Cells from Apoptosis through Stat6-dependent Up-regulation of Bcl-xL Journal of Biological Chemistry. ,vol. 277, pp. 27169- 27175 ,(2002) , 10.1074/JBC.M201207200
A. D. Keegan, J. A. Johnston, P. J. Tortolani, L. J. McReynolds, C. Kinzer, J. J. O'Shea, W. E. Paul, Similarities and differences in signal transduction by interleukin 4 and interleukin 13: Analysis of Janus kinase activation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 7681- 7685 ,(1995) , 10.1073/PNAS.92.17.7681
Pascale Chomarat, Jacques Banchereau, Interleukin-4 and lnterleukin-13: Their Similarities and Discrepancies International Reviews of Immunology. ,vol. 17, pp. 1- 52 ,(1998) , 10.3109/08830189809084486
Nicholas I. Obiri, Waldemar Debinski, Warren J. Leonard, Raj K. Puri, Receptor for Interleukin 13: INTERACTION WITH INTERLEUKIN 4 BY A MECHANISM THAT DOES NOT INVOLVE THE COMMON γ CHAIN SHARED BY RECEPTORS FOR INTERLEUKINS 2, 4, 7, 9, AND 15 Journal of Biological Chemistry. ,vol. 270, pp. 8797- 8804 ,(1995) , 10.1074/JBC.270.15.8797
Mark Boothby, Ana L. Mora, Linda M. Stephenson, Lymphokine-dependent proliferation of T-lymphoid cells: regulated responsiveness and role in vivo. Critical Reviews in Immunology. ,vol. 21, pp. 487- 522 ,(2001) , 10.1615/CRITREVIMMUNOL.V21.I6.20
Ann E Kelly-Welch, Erica M Hanson, Mark R Boothby, Achsah D Keegan, Interleukin-4 and Interleukin-13 Signaling Connections Maps Science. ,vol. 300, pp. 1527- 1528 ,(2003) , 10.1126/SCIENCE.1085458
D. J. Hilton, J. G. Zhang, D. Metcalf, W. S. Alexander, N. A. Nicola, T. A. Willson, Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 497- 501 ,(1996) , 10.1073/PNAS.93.1.497
Robin E. Callard, David J. Matthews, Linda Hibbert, IL-4 and IL-13 receptors: are they one and the same? Immunology Today. ,vol. 17, pp. 108- 110 ,(1996) , 10.1016/0167-5699(96)80600-1