The Accumulation and Histological Effects of The Organometallic Fungicide Propineb on The Organs of Fetuses and Female Rats During Pregnancy

摘要: Dithiocarbamate propineb is an organometal fungicide, which widely used for the control of diseases in plants. Female Wistar rats were exposed orally to concentrations 200 and 400 ppm, from 6th day gestation up birth. At showed a variety macroscopic (e.g. ptosis paralysis) microscopic symptoms organs both fetuses female rats. We found that body weights one-day old litters their propineb-treated mothers lower than those controls. Histological examination livers kidneys pregnant females histopathological effects. The analysis Zn (using Inductively Coupled Plasma-Atomic Emission Spectrometry) liver, kidney heart organometallic fungicide during pregnancy demonstrated metal these higher However, hepatic, renal myocardial greatly increased subjected gestation, indicating high levels trace may well be due easily passing placental barrier.