Understanding stress in the healthy animal - potential paths for progress.

摘要: Although stress is usually associated with disease, the physiological and behavioral responses to stressors are critical mechanisms of resilience for healthy organisms. A recent workshop comprised researchers who study humans both free-living captive non-human animals identified a number key roadblocks that impeding progress in understanding how integrate into normal physiology an animal. These include lack of: (1) unambiguous definition phenotype; (2) robust biomarker, or suite biomarkers, indicate (3) theoretical quantitative models predict other will react stressors; (4) comprehensive individual variability arise (5) transitions between acute chronic responses. Collectively, these deficiencies impair our ability assess status individuals develop procedures techniques reverse effects elicited by before they become pathological. Workshop participants also potential approaches facilitate on problems. They include: increased use mathematical provide predictions; network theory expose emergent properties not predicted from traditional approaches; development deployment improved sensor technology allow long-term, dynamic, non-invasive, multi-factor measurements suites mediators recruitment scientists diverse skill sets, such as engineers, bioinformaticians, etc.; training young multidisciplinary stress. Incorporating new research should reinvigorate stimulate cope animals, including rapidly changing environment.