An efficient, mild and solvent-free synthesis of benzene ring acylated harmalines.
作者： Sabira Begum , Farhat Zubair , Syed Nawazish Ali , Bina Shaheen Siddiqui
DOI: 10.3390/MOLECULES15010068
关键词:
摘要: A facile synthesis of a series benzene ring acylated analogues harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl3. The reaction afforded 10- 12-acyl in good yield, along with minor quantities N-acyl-tryptamines 8-acyl N-acyltryptamines.
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